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. 2010 Oct 30;8:106. doi: 10.1186/1479-5876-8-106

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Copyright ©2010 Siebert et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Long-term frequency changes for the T_CMconsensus phenotype, CCR7+CD45RA-CD57-CD27+CD28+ (+--++) and two associated supersets. (A) Plot illustrating the statistically significant increase in the T_CMconsensus phenotype frequency between PIVR and LTM for all 7 patients. (B) The concomitant decrease between LTM and P2B for the frequency of the consensus T_CMphenotype. (C) The longitudinal expression profile for the T_CMconsensus phenotype showing LTM peaks for 4 of 7 patients; longitudinal profile for the CD45RA unspecified superset, CCR7+CD57-CD27+CD28+ (+.-++), showing LTM peaks for 6 of 7 patients; and longitudinal profile for the CD45RA, CD27, and CD28 unspecified superset, CCR7+CD57- (+.-..), also showing LTM peaks for 6 of 7 patients. Data suggests CD45RA, CD27, and CD28 may not be obligate descriptors for central memory T cells.