Table 7.

The role of leptin in lung cancer

Reference (year)	Main messages	Main limitations
Ribeiro et al138 (2006)	Polymorphism in the promoter of leptin gene associated with increased risk for NSCLC	Controls younger than patient group/Smoking status of controls unknown
Aleman et al142 (2002)	Lower leptin in NSCLC vs controls	No adjustment for FM/Only advanced stage disease
Karapanagiotou et al146 (2008)	No association of leptin to histological type, differentiation grade, disease stage, survival or time to disease progression	Controls and patients not age and sex matched/ Only advanced stage disease
Carpagnano et al147 (2007)	Higher leptin in NSCLC vs controls	No adjustment for FM/Limited number o f patients/Non-advanced disease stage

Abbreviations: NSCLC: Non small cell lung cancer, FM: Fat mass