Table 5.
Herpes viruses and clinical parameters in pediatric lymphoma patients
| Factor | HHV6 n(%) | CMV n(%) | Both n(%) | Negative n(%) | p value |
|---|---|---|---|---|---|
| Fever n = 22 | 3(14) | 3(14) | 7(32) | 9(40) | 0.100 |
| Rash n = 9 | 0(0) | 1(11) | 2(22) | 6(67) | 0.479 |
| Organomegaly n = 13 | 2(15) | 1(8) | 2(15) | 8(62) | 0.526 |
| Med. mass n = 18 | 2(11) | 4(22) | 2(11) | 10(56) | 0.869 |
| Mucositis n = 10 | 2(20) | 1(10) | 7(70) | 0(0) | < 0.001 |
| Other infection n = 14 | 3(21) | 0(0) | 8(58) | 3(21) | 0.004 |
| Duration of FN (n = 28) | |||||
| Low Risk (< 10 d) n = 15 | 1(7) | 3(20) | 2(13) | 9(60) | 0.136 |
| High Risk (≥ 10 d) n = 13 | 2(15) | 0(0) | 7(54) | 4(31) | |
| ANC (Median = 0.8) | |||||
| Mild(≥ 0.8)n = 25 | 3(12) | 6(24) | 1(4) | 15(60) | 0.570 |
| Severe (< 0.8)n = 25 | 3(12) | 1(4) | 9(36) | 12(48) | |
| Plt count | |||||
| ≥96 n = 25 | 4(16) | 5(20) | 2(8) | 14(56) | 1.000 |
| < 96 n = 25 | 2(8) | 2(8) | 8(32) | 13(52) | |
| Hb | |||||
| ≥ 9.1 n = 25 | 3(12) | 5(20) | 1(4) | 16(64) | 0.256 |
| < 9.1 n = 25 | 3(12) | 2(8) | 9(36) | 11(44) | |
| Mono | |||||
| ≥ 0.4 n = 25 | 3(12) | 5(20) | 2(8) | 15(60) | 0.570 |
| < 0.4 n = 25 | 3(12) | 2(8) | 8(32) | 12(48) | |
| Lymph | |||||
| ≥ 0.5 n = 25 | 3(12) | 4(16) | 1(4) | 17(68) | 0.089 |
| < 0.5 n = 25 | 3(12) | 3(12) | 9(36) | 10(40) |
Med. Mass: Mediastinal mass, FN: Febrile neutropenia, ANC: absolute neutrophil count, Plt: Platelet count, Hb: hemoglobin concentration, Mono: monocyte, Lymph: Lymphocyte, HHV6: herpes virus 6 single infection, CMV: cytomegalovirus single infection, Both: positive for HHV6/CMV DNA, Negative: negative for herpes viruses