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. 2010 Oct 28;10:590. doi: 10.1186/1471-2407-10-590

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Copyright ©2010 Maurya et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Administration of rat UCMSCs significantly attenuated the growth of LLC tumors in a syngeneic mouse model. Panel A shows that lung weight in mice transplanted with one million LLC cells declines almost to non-cancerous control levels after a single intratracheal administration of rat UCMSCs (0.35 million cells). Panel B shows that systemic transplantation of rat UCMSCs (one million cells twice) also significantly decreased the weight of the LLC-bearing lungs despite a marked increase of tumor burden due to a larger number of LLC cells transplanted (two million cells). In both experiments, eight mice per group were used except for the rat UCMSCs intratracheally administered group, which consisted of nine mice.