Table 3.

Workflow time table

Approval of ethics committee

↓

Diagnosis of chordoma of the skull base and completion of pre-radiation treatment examinations (biopsy, operation, staging)

↓

Informed consent of the patient and patient registration by the study office at HIT

↓

Stratification and Randomisation

↓

Arm A: carbon ion RT (63 Gy E ± 5%, fractionation 4-6 × 3.0 Gy E) Arm B: proton RT (72 Gy E ± 5%, fractionation 4-6 × 2.0 Gy E)

↓

Treatment planning for particle therapy

↓

Particle therapy

↓

Follow-up