Table 3. B.
Top 50 genes with at least 2-fold lower expression in F9 Wt cells relative to F9 RARγ−/− cells after 24 h in the absence of RA. Fold change =WT/RARγ−/−.
| Affymetrix ID | Fold Changeab | Gene Symbol | Gene Title |
|---|---|---|---|
| 1436796_at | 0.307 | 1110061A14Rik | matrin 3 |
| 1422557_s_at | 0.305 | Mt1 | Metallothionein 1 |
| 1450292_a_at | 0.305 | Ap3b1 | Adaptor-related protein complex 3, beta 1 subunit |
| 1448991_a_at | 0.302 | Ina | Internexin neuronal intermediate filament protein, alpha |
| 1450417_a_at | 0.301 | Rps20 | ribosomal protein S20 |
| 1457195_at | 0.299 | Plekhm1 | cDNA sequence BC038943 |
| 1424490_at | 0.292 | Atp5o | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
| 1454681_at | 0.288 | 2210008M09Rik | cDNA sequence BC031468 |
| 1429490_at | 0.286 | Rif1 | Rap1 interacting factor 1 homolog (yeast) |
| 1417751_at | 0.285 | Mapk7 | Mitogen activated protein kinase 7 |
| 1418994_at | 0.283 | 2410116G06Rik | RIKEN cDNA 2410116G06 gene |
| 1437311_at | 0.279 | A930034L06Rik | RIKEN cDNA A930034L06 gene |
| 1425415_a_at | 0.255 | Slc1a1 | Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| 1416149_at | 0.252 | Akt2 | Thymoma viral proto-oncogene 2 |
| 1436619_at | 0.251 | H3077A05-3 NIA Mouse 15K cDNA Clone Set Mus musculus cDNA clone H3077A05 3′, mRNA sequence. | |
| 1460204_at | 0.251 | Tsc2 | Tuberous sclerosis 2 |
| 1427046_at | 0.246 | 1810073N04Rik | RIKEN cDNA 1810073N04 gene |
| 1423281_at | 0.246 | Stmn2 | stathmin-like 2 |
| 1440997_at | 0.246 | 9930033H14Rik | RIKEN cDNA 9930033H14 gene |
| 1455688_at | 0.245 | AI838577 | Adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530036D08 product:unknown EST, full insert sequence |
| 1439880_at | 0.238 | D630023F18Rik | Transcribed sequences |
| 1453219_a_at | 0.231 | L1td1 | LINE-1 type transposase domain containing 1 |
| 1425035_s_at | 0.23 | Dnmt3l | DNA (cytosine-5-)-methyltransferase 3-like |
| 1421299_a_at | 0.229 | Lef1 | Lymphoid enhancer binding factor 1 |
| 1423280_at | 0.226 | Stmn2 | stathmin-like 2 |
| 1458599_at | 0.223 | Transcribed sequences | |
| 1443858_at | 0.218 | Trim34 | RIKEN cDNA 9230105E10 gene |
| 1448299_at | 0.217 | Slc1a1 | Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| 1436388_a_at | 0.213 | 3830406C13Rik | RIKEN cDNA 3830406C13 gene |
| 1425926_a_at | 0.199 | Otx2 | Orthodenticle homolog 2 (Drosophila) |
| 1460386_a_at | 0.197 | Slc1a1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| 1418825_at | 0.195 | Psmd11 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
| 1433789_at | 0.158 | Rnu17d | 18 days pregnant adult female placenta and extra embryonic tissue cDNA, RIKEN full-length enriched library, clone:3830421G02 product:unknown EST, full insert sequence |
| 1445271_at | 0.151 | 9230105E10Rik | RIKEN cDNA 9230105E10 gene |
| 1445617_at | 0.15 | Transcribed sequences | |
| 1439207_at | 0.149 | Similar to paraneoplastic antigen like 5; paraneoplastic antigen family 5 (LOC386569), mRNA | |
| 1423327_at | 0.133 | D730048I06Rik | RIKEN cDNA D730048I06 gene |
| 1429203_at | 0.131 | 2410076I21Rik | RIKEN cDNA 2410076I21 gene |
| 1433792_at | 0.131 | AW491344 | Transcribed sequence with weak similarity to protein ref:NP_113662.1 (H. sapiens) hypothetical protein DKFZp761G1913 [Homo sapiens] |
| 1448558_a_at | 0.118 | Pla2g4a | Phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| 1422617_at | 0.102 | Top1 | Topoisomerase (DNA) I |
| 1429701_at | 0.101 | 2410003J06Rik | RIKEN cDNA 2410003J06 gene |
| 1434739_at | 0.0949 | 3830422N12Rik | RIKEN cDNA 3830422N12 gene |
| 1453544_at | 0.0876 | 4933424F23Rik | RIKEN cDNA 4933424F23 gene |
| 1449625_at | 0.0707 | Transcribed sequence with weak similarity to protein ref:NP_570953.1 (M. musculus) CAMP [Mus musculus] | |
| 1419241_a_at | 0.0671 | Aire | Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) |
| 1420357_s_at | 0.0663 | Fndc6 | Fibronectin type III domain containing 6 |
| 1447021_at | 0.0447 | CDNA clone MGC:61032 IMAGE:30024827, complete cds | |
| 1448889_at | 0.0344 | Slc38a4 | Solute carrier family 38, member 4 |
| 1428111_at | 0.028 | Slc38a4 | Solute carrier family 38, member 4 |
| 1423523_at | 0.0225 | Aass | aminoadipate-semialdehyde synthase |
a
Average from three experiments.
b
Some genes have multiple distinct probes on the GeneChip® resulting in different fold-changes from different probes.