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. Author manuscript; available in PMC: 2010 Nov 22.
Published in final edited form as: Nat Rev Microbiol. 2010 Apr 7;8(5):350–360. doi: 10.1038/nrmicro2332

Table 1.

Subsets of human DCs

Plasmacytoid DCs Myeloid subtypes (Stellate DCs)
Myeloid DCs Langerhans Interstitial DCs Monocyte Monocyte-derived DCs
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Localisation Blood Blood Epidermal Dermis and other tissues in vitro
Phenotype CD1a+ CD1a+ CD1a+ CD1a − CD1a+
CD1c− CD1c+ CD11c+ CD11c+ CD1c+
CD11c− CD11c+ Langerin+ CD68+ CD11c+
CD123 high CD123 low 1, 2, 3, 6, 7, 8 Factor XIIIa CD123 low
CD304 + CD304 − Langerin 1,2, 3, 4, 5, 6, 7, 8, 1,2, 3, 4, 5, 6, 8, 10
TLR expression 1, 6, 7, 9, 10 1,2, 3, 4, 5, 6, 8, 10 + MR MR DC-SIGN DCIR
C-type lectin expression DCIR BDCA-2 DCIR (MR) (DC-SIGN) + DC DC-SIGN +
Immunological function
CD4+ T cel cell priming + + +/− + +
CD8+ T cell priming + + + + +
B cell activation + + + +
IFN-α production +++ + + +

Abbreviations: BDCA, blood dendritic cell antigen; DCs, dendritic cells; DC-SIGN, dendritic-cell specific ICAM3 grabbing non-integrin; IFN, interferon; DCIR, dendritic cell immunoreceptor; MR, mannose receptor; TLR, Toll-like receptor