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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Neurobiol Aging. 2010 Jun 30;33(4):804–813. doi: 10.1016/j.neurobiolaging.2010.05.018

Figure 4. AP4 overexpression or knockdown suppresses or enhances Pin1 protein levels, respectively.

Figure 4

(A) Overexpression of AP4 in H4 neuronal cells significantly suppressed the expression on Pin1 whereas AP4 knockdown by shRNA increased the expression of Pin1. (B) Graph obtained from three independent experiments showing overexpression of AP4 resulted in an 80% reduction of Pin1 expression but AP4 knockdown increased the expression of Pin1 by two fold.