Table 2.
A list of selected significantly up-regulated and down-regulated genes in HepG2 cells treated with methanolic extracts of T. indica fruit pulp that may be related to stress response (A), lipid metabolic processes (B) and others (C)
| Genebank ID | Protein (gene name) | Fold change (treated vs. untreated) |
|---|---|---|
| Stress response | ||
| NM_176870 | Metallothionein 1 M (MT1M) | 5.21 |
| NM_005949 | Metallothionein 1F (MT1F) | 2.35 |
| NM_005952 | Metallothionein 1X (MT1X) | 1.68 |
| NM_145740 | Glutathione S-transferases (GSTA1) | 2.80 |
| NM_000846 | Glutathione S-transferases (GSTA2) | 1.60 |
| NM_183239 | Glutathione S-transferases (GSTO2) | 1.73 |
| Lipid metabolic process | ||
| NM_000482 | Apolipoprotein A-IV (APOA4) | 2.31 |
| NM_052968 | Apolipoprotein A-V (APOA5) | 1.90 |
| NM_022436 | ATP-binding cassette, subfamily G (WHITE), member 5 (ABCG5) | 1.84 |
| NM_000253 | Microsomal triglyceride transfer protein (MTTP) | −1.80 |
| Others | ||
| NM_000921 | Phosphodiesterase 3A, cGMP-inhibited (PDE3A) | −5.10 |
| NM_000499 | Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) | −3.61 |
| NM_004590 | Chemokine (C–C motif) ligand 16 (CCL16) | −4.36 |
| NM_004219 | Pituitary tumour-transforming 1 (PTTG1) | −2.93 |
| NM_199246 | Cyclin G1 (CCNG1) | −2.31 |
| NM_004701 | Cyclin B2 (CCNB2) | −2.24 |
| NM_004354 | Cyclin G2 (CCNG2) | −1.97 |
| NM_001237 | Cyclin A2 (CCNA2) | −1.93 |
| NM_001786 | Cell division cycle 2, G1 to S and G2 to M (CDC2) | −1.85 |
| NM_031966 | Cyclin B1 (CCNB1) | −1.78 |
Details of the GenBank accession number, name of the gene and its respective protein and fold change difference between treated and non-treated cells are included