Table 2.
Clinical and Histological Parameters of BKVN Patients
| BKVN-DFa N=8 (%) |
BKVN-SFa N=10 (%) |
P Valueb | |
|---|---|---|---|
| Baseline Parameters | |||
| Age (mean± SD) | 52± 6 | 51 ±13 | 0.85 |
| Gender (% male) | 8 (100%) | 5 (50%) | 0.04 |
| Deceased Donor grafts (%) | 4(50%) | 7 (70%) | 0.63 |
| ATG induction (%) | 3 (38%) | 5 (50%) | 0.66 |
| Steroid Maintenance (%) | 4 (50%) | 6 (60%) | 1.0 |
| Biopsy Creatinine (mean±SD) |
2.79±0.5 | 2.03±0.7 | 0.02 |
| Time from Transplant to Biopsy (Months, mean±SD) |
11.6±10.4 | 11.7±6.5 | 0.51 |
|
Histological Grades &
Scores (mean±SD) | |||
| PVAN Grade | 3 A, | 6 A , | 0.41c |
| (Drachenberg Stage [15]) | 2 B, | 2 B, | |
| 3 C | 2 C | ||
| Cytopathic score | 1.4±0.26 | 1.5 ± 0.27 | 0.75 |
| Tubulitis score | 1.3±0.25 | 1.1±0.32 | 0.73 |
| Infiltrate score | 1.9±0.4 | 1.6±0.4 | 0.64 |
| Tubular atrophy score | 1.8±041 | 1.1±0.23 | 0.17 |
| Interstitial Fibrosis score | 1.25±0.31 | 0.8±0.13 | 0.17 |
| BKVN Treatment | |||
| IVIG Therapy (%) | 4 (50%) | 8 (80%) | 0.32 |
| Leflunomide Therapy (%) | 3 (38%) | 6 (60%) | 0.64 |
a
The BKVN patients with an increase in the level of serum creatinine of ≥0.5mg/dl during the one-year following BKVN diagnosis were classified as the Decline in Function Group (BKVN-DF) and the BKVN patients without such an increase were classified as the Stable Function Group (BKVN-SF).
b
Categorical variables were compared using Fisher’s Exact Test; Continuous variables were compared using Mann Whitney Test
c
PVAN grades were compared using Jonckheere-Terpstra Exact test for Trend.