Figure 4. Duration of each seizure stage during the initial and later seizure clusters.

The durations (in seconds) of seizures within each seizure stage were determined by randomized sampling for the initial cluster (A) and all of the later clusters combined (B) in the depth-electrode implanted, MSO-treated animals. The data are indicated by boxplots and vertical point plots (which are superimposed on the boxplots) for the initial cluster (A) and all of the later clusters combined (B), in the depth-electrode implanted, MSO-treated animals. The median duration of subclinical seizures is significantly shorter than the median duration of seizures of the other stages in the later clusters (difference indicated by asterisk; p < 0.001, Kruskal-Wallis analysis followed by Dunn’s test, n = 16). Moreover, the median duration of Stage III seizures is shorter in the later clusters than the initial cluster (p < 0.01, Mann-Whitney Rank Sum test, difference not indicated by asterisk). Due to the very small number of Stage V seizures, no such seizures were sampled in the analysis of seizure duration; hence, the absence of data from Stage V. See the legend to Fig. 2 for an explanation of the plots.