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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Immunol. 2010 Oct 29;185(11):6939–6946. doi: 10.4049/jimmunol.1002484

FIGURE 4. IgG1 KO mice have stronger and earlier IgG3 responses.

FIGURE 4

A, IgG1 KO and B6 WT mice were infected, as in Fig. 2 and serum samples (collected at the times shown) were evaluated for L. mexicana-specific IgG3 by ELISA. *p < 0.05 at all dilutions. B, The kinetics of L. mexicana-specific IgG3 levels were determined. The ratio of relative abundances (IgG1 KO/B6 WT) is shown for each time point. *p < 0.02. C, Sera from IgG1 KO and B6 WT mice infected with L. mexicana for 12 wk were depleted of IgG1 and then ELISAs were performed for IgG3. *p < 0.05 for IgG1 KO versus other groups; p > 0.05 for B6 WT versus B6 WT-IgG1 depleted (paired t test). Undepleted samples received streptavidin beads without biotinylated anti-IgG1.