Figure 1.
LPA1 receptor-dependent and -independent demyelination after nerve injury in toluidine blue analysis. Toluidine blue analysis was performed at day 7 post-injury. (a) Representative photographs of DR (dorsal root), SPN (spinal nerve) and SCN (sciatic nerve) regions in WT or Lpar1-/- mice. Arrow indicates a demyelinated fiber. Scale bar, 10 μm. (b) Quantification of demyelinated fibers. Data are expressed as a percentage of total fibers in each region. *p < 0.05, vs. WT and sham-operated mice and #p < 0.05, vs. WT and nerve-injured mice. Results represent the mean ± SEM from 3-5 independent experiments.