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Analysis of LPA1 receptor-dependent and -independent Remak bundle disruption by TEM. TEM analysis was performed at day 7 post-injury. Photographs show representative data on C-fiber-containing Remak bundles in dorsal root (DR), spinal nerve (SPN) and sciatic nerve (SCN) fibers in WT or Lpar1-/- mice. Arrow indicates a direct contact between C-fibers in the Remak bundle. Scale bar, 5 μm.
