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Pharmacokinetic analysis of MB following peripheral administration. (A) A single intravenous (I.V.) administration of 20 mg/kg MB was given to wildtype mice at different time points (n = 3 per time point), and cerebellar and plasma concentrations were measured through LC-MS. (B) A single 200 mg/kg oral gavage bolus of MB was given to wildtype mice at different time points (n = 3 per time point) and also measured by LC-MS. Cerebellar brain concentrations of MB are higher than plasma.
