Table 1.
Promoter methylation and expression correlation of Cyclin D2 and PTCH1 gene in medulloblastoma cell lines
| Cell lines | Cyclin D2 expression | Cyclin D2 promoter hypermethylation by MCA-Meth | Cyclin D2 Hypermethylation by MSP | Cyclin D2 Hypermethylation by both methods | No Hyper Methylation in Cyclin D2 Promoter | PTCH1 Expression in medulloblastoma cell lines | PTCH1 promoter Hypermethylation by MCA-MSP method |
|---|---|---|---|---|---|---|---|
| TE671 | ++ | U | M | ++ | U | ||
| PFSK-1 | ++ | M | M | √ | ++ | U | |
| Daoy | ++ | U | U+M | ++ | U | ||
| TE671c2 | ++ | U | U+M | + | U | ||
| D283 | ++ | U | U + M | + | U+M | ||
| SK-PN-DW | + | U+M | M | √ | + | U | |
-: no expression; +: expression; ++: high expression; √: yes