Table 2.
Promoter methylation and expression correlation of Cyclin D2 and PTCH1 gene in medulloblastoma samples
| MB samples ID | Patients' Date of Birth (D/M/Y) | Sex | Expression of Cyclin D2 in primary tumor samples | Promoter methylation by MCA-Meth in Cyclin D2 | Promoter methylation by MSP in Cyclin D2 | No Promoter hypermethylation in Cyclin D2 | Expression of PTCH1 in primary tumor samples | Promoter hypermethylation in PTCH1 by MCA-Meth of PTCH1 |
|---|---|---|---|---|---|---|---|---|
| p3 | 5/18/1969 | M | ++ | U | U | √ | - | U + M |
| p4 | 3/9/1987 | M | - | U | U + M | + | U | |
| p7 | 11/27/1987 | M | ++ | U | U | √ | + | U |
| p10 | 4/15/1971 | M | ++ | U | U | √ | nd | U |
| p11 | 4/30/1997 | F | + | U | U + M | - | U + M | |
| p13 | 8/21/1995 | F | + | U | U + M | nd | U | |
| p14 | 9/9/1991 | F | ++ | U | U | √ | + | U |
| p17 | 11/30/1988 | M | ++ | U | U | √ | + | U |
| p20 | 11/22/1978 | M | ++ | U | U | √ | + | U |
| p21 | 11/15/1987 | M | ++ | U | U | √ | + | U |
| p29 | 3/9/1974 | M | ++ | U | U | √ | nd | U |
| p30 | 6/24/1991 | M | ++ | U | U | √ | nd | nd |
| p23 | 8/15/1984 | F | nd | nd | nd | nd | nd | nd |
| p52 | 10/5/1991 | M | nd | nd | nd | nd | nd | nd |
MB: medulloblastoma; -: no expression; +: expression; ++: high expression; √: yes