Table 3.
Metabolic and cellular processes affected by bilberry anthocyanin-rich extract in the liver of apo E−/− mice using Pathway Miner analyses
| Pathways | Total (n) | Up-regulated genes (n) | Down-regulated genes (n) |
|---|---|---|---|
| Babelomics | |||
| Metabolic process | |||
| Energy and lipid metabolism | |||
| Oxidative phosphorylation | 9 | 6 | 3 |
| Arachidonic acid metabolism | 11 | 5 | 6 |
| Fatty acid metabolism | 11 | 6 | 5 |
| Glycerophospholipid metabolism | 10 | 5 | 5 |
| Glycerolipid metabolism | 6 | 4 | 2 |
| Bile acid biosynthesis | 3 | 2 | 1 |
| Biosynthesis of steroids | 3 | 3 | 0 |
| Fatty acid biosynthesis | 2 | 2 | 0 |
| Cellular process | |||
| Cell migration and communication | |||
| Regulation of actin cytoskeleton | 31 | 19 | 12 |
| Cell Communication | 21 | 14 | 7 |
| Focal adhesion | 27 | 17 | 10 |
| Leukocyte transendothelial migration | 18 | 9 | 9 |
| Cell adhesion molecules (CAMs) | 17 | 7 | 10 |
| Inflammation | |||
| Natural killer cell mediated cytotoxicity | 13 | 7 | 6 |
| T cell receptor signalling pathway | 12 | 6 | 6 |
| Complement and coagulation cascades | 11 | 6 | 5 |
| Signalling | |||
| Neuroactive ligand-receptor interaction | 46 | 25 | 21 |
| MAPK signalling pathway | 36 | 16 | 20 |
| Cytokine-cytokine receptor interaction | 23 | 14 | 9 |
| Jak-STAT signalling pathway | 15 | 10 | 5 |
| GenMAPP | |||
| Metabolic process | |||
| Statin pathway | 5 | 4 | 1 |
| Electron Transport Chain | 5 | 3 | 2 |
| Steroid Biosynthesis | 3 | 1 | 2 |
| Mitochondrial fatty acid betaoxidation | 3 | 3 | 0 |
| Cellular process | |||
| Regulation of actin cytoskeleton | 24 | 14 | 10 |
| Integrin-mediated cell adhesion | 17 | 6 | 11 |
| TGF Beta Signalling Pathway | 10 | 6 | 4 |
| Nuclear receptors | 6 | 3 | 3 |
| Inflammatory Response Pathway | 3 | 2 | 1 |
| Complement Activation Classical | 2 | 0 | 2 |
| Biocarta | |||
| Metabolic process | |||
| SREBP control of lipid synthesis | 3 | 2 | 1 |
| FXR and LXR regulation of cholesterol metabolism | 2 | 2 | 0 |
| Cellular process | |||
| Nuclear receptors in lipid metabolism and toxicity | 11 | 8 | 3 |
| PDGF signalling pathway | 8 | 5 | 3 |
| TNFR1 signalling pathway | 6 | 4 | 2 |
| CXCR4 signalling pathway | 6 | 4 | 2 |
| IL-10 anti-inflammatory signalling pathway | 3 | 2 | 1 |