Table 2.
Colon Nrf2 target genes responding to selenium supply as measured by microarray analysis
| Gene name | Description | Acc. number | P value | FC | Reference |
|---|---|---|---|---|---|
| Abcb1a (Mdr3) | ATP-binding cassette, subfamily B (MDR/TAP), member 1A | NM_011076 | 0.139 | 1.11 | |
| Abcb1b (Mdr1) | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | NM_011075 | 0.138 | 1.09 | [24] |
| Abcc1 (Mrp1) | ATP-binding cassette, subfamily C (CFTR/MRP), member 1 | NM_008576 | 0.0003 | 0.83 | [15] |
| Abcc4 (Mrp4) | ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | NM_001033336 | 0.004 | 1.23 | [36] |
| Abcg5 | ATP-binding cassette, subfamily G (WHITE), member 5 | NM_031884 | 0.028 | 1.22 | [47] |
| Aldh1a1 | Aldehyde dehydrogenase family 1, subfamily A1 | NM_013467 | 0.133 | 1.21 | [34] |
| Aldh1a3 | Aldehyde dehydrogenase family 1, subfamily A3 | NM_053080 | 0.040 | 1.20 | |
| Aldh1a7 | Aldehyde dehydrogenase family 1, subfamily A7 | NM_011921 | 0.028 | 1.12 | [34, 47] |
| Aldh3a2 | Aldehyde dehydrogenase family 3, subfamily A2 | NM_007437 | 0.120 | 1.16 | [47] |
| Aldh9a1 | Aldehyde dehydrogenase 9, subfamily A1 | NM_019993 | 0.002 | 1.31 | |
| Blvrb | Biliverdin reductase B (flavin reductase (NADPH)) | NM_144923 | 0.106 | 1.14 | [40] |
| Cat | Catalase | NM_009804 | 0.760 | 1.03 | [11] |
| Ces1 | Carboxylesterase 1 | NM_021456 | 0.109 | 1.20 | [47] |
| Ces2 | Carboxylesterase 2 | NM_145603 | 0.004 | 0.72 | [47] |
| Ephx1 | Epoxide hydrolase 1, microsomal | NM_010145 | 0.563 | 1.04 | [6] |
| Esm1 | Endothelial cell-specific molecule 1 | NM_023612 | 0.011 | 1.16 | [41] |
| Fth1 | Ferritin heavy chain 1 | NM_010239 | 0.098 | 1.29 | [41] |
| G6pdx | Glucose-6-phosphate dehydrogenase X-linked | NM_008062 | 0.057 | 1.19 | [54] |
| Gclc | Glutamate-cysteine ligase, catalytic subunit | NM_010295 | 0.048 | 0.80 | [37] |
| Gclm | Glutamate-cysteine ligase, modifier subunit | NM_008129 | 0.038 | 0.88 | [37] |
| Gpx2 | Glutathione peroxidase 2 | NM_030677 | 0.065 | 0.67 | [5] |
| Gsr | Glutathione reductase 1 | NM_010344 | 0.401 | 1.12 | [54] |
| Gss | Glutathione synthetase | NM_008180 | 0.044 | 0.74 | [33] |
| Gsta1 | Glutathione S-transferase, alpha 1 (Ya) | NM_008181 | 0.264 | 1.15 | [21] |
| Gsta2 | Glutathione S-transferase, alpha 2 (Yc2) | NM_008182 | 0.073 | 1.15 | [21] |
| Gsta3 | Glutathione S-transferase, alpha 3 | NM_001077353 | 0.329 | 1.12 | [21] |
| Gsta4 | Glutathione S-transferase, alpha 4 | NM_010357 | 0.001 | 1.18 | [21] |
| Gstm1 | Glutathione S-transferase, mu 1 | NM_010358 | 0.272 | 1.22 | [21] |
| Gstm5 | Glutathione S-transferase, mu 5 | NM_010360 | 0.027 | 1.30 | [21] |
| Gstm7 | Glutathione S-transferase, mu 7 | NM_026672 | 0.080 | 1.29 | |
| Gstp1 | Glutathione S-transferase, pi 1 | NM_013541 | 0.141 | 0.80 | [19] |
| Gusb | Glucuronidase, beta | BC004616 | 0.013 | 1.15 | |
| Hmox1 | Heme oxygenase (decycling) 1 | NM_010442 | 0.025 | 1.09 | [11] |
| Mt1 | Metallothionein 1 | NM_013602 | 0.010 | 1.32 | [59] |
| Mt2 | Metallothionein 2 | NM_008630 | 0.019 | 1.57 | [59] |
| Nat13 | N-acetyltransferase 13 | NM_028108 | 0.001 | 1.21 | |
| Nat3 | N-acetyltransferase 3 | NM_008674 | 0.002 | 1.29 | |
| Nat8 l | N-acetyltransferase 8-like | NM_001001985 | 0.038 | 1.15 | |
| Nqo1 | NAD(P)H dehydrogenase, quinone 1 | NM_008706 | 0.589 | 1.04 | [11, 56] |
| Pgd | Phosphogluconate dehydrogenase | BC011329 | 0.007 | 0.72 | [54] |
| Pir | Pirin | NM_027153 | 0.312 | 1.10 | [18] |
| Prdx1 | Peroxiredoxin 1 | NM_011034 | 0.092 | 1.32 | [20, 27] |
| Prdx2 | Peroxiredoxin 2 | NM_011563 | 0.229 | 1.20 | |
| Prdx4 | Peroxiredoxin 4 | NM_016764 | 0.026 | 1.34 | |
| Sod1 | Superoxide dismutase 1, soluble | NM_011434 | 0.012 | 1.54 | [11] |
| Sqstm1 | Sequestosome 1 (A170 stress protein) | NM_011018 | 0.037 | 1.28 | [20] |
| Srxn1 | Sulfiredoxin 1 homolog | NM_029688 | 0.128 | 1.17 | [4] |
| Sult1b1 | Sulfotransferase family 1B, member 1 | NM_019878 | 0.016 | 1.26 | [2] |
| Sult1c2 | Sulfotransferase family, cytosolic, 1C, member 2 | NM_026935 | 0.039 | 1.21 | [2] |
| Tkt | Transketolase | NM_009388 | 0.904 | 1.01 | [18] |
| Txn1 | Thioredoxin 1 | NM_011660 | 0.377 | 1.11 | [26] |
| Txn2 | Thioredoxin, mitochondrial protein | U85089 | 0.154 | 1.12 | [26] |
| Txnrd1 | Thioredoxin reductase 1 (Txnrd1), transcript variant 1 | NM_001042523 | 0.572 | 0.94 | [17] |
| Ugdh | UDP-glucose dehydrogenase | NM_009466 | 0.300 | 1.14 | [47] |
| Ugp2 | UDP-glucose pyrophosphorylase 2 | NM_139297 | 0.753 | 1.02 | [47] |
| Ugt1a1 | UDP glucuronosyltransferase 1 family, polypeptide A1 | NM_201645 | 0.981 | 1.00 | [60] |
| Ugt1a6b | UDP glucuronosyltransferase 1 family, polypeptide A6B | NM_201410 | 0.217 | 1.26 | [11] |
| Ugt2b34 | UDP glucuronosyltransferase 2 family, polypeptide B34 | NM_153598 | 0.004 | 0.82 | [47] |
| Ugt2b37 | UDP glucuronosyltransferase 2 family, polypeptide B37 | NM_053215 | 0.009 | 1.26 | |
| Ugt2b5 | UDP glucuronosyltransferase 2 family, polypeptide B5 | NM_009467 | 0.020 | 1.20 |
Genes are sorted based on gene name. Fold change (FC) numbers in bold indicate an up-regulation in selenium-deficiency (FC > 1.1). Gene names in bold indicate analysis by qPCR. Gene names in italic point to selenoprotein genes