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. 2010 Nov 3;30(44):14708–14718. doi: 10.1523/JNEUROSCI.1637-10.2010

Figure 2.

Figure 2.

Activation of the TrkB receptor in YAC128 and BTg mice. A–C, Representative Western blots showing levels of TrkB receptors, downstream effectors (Akt, Erk1/2, and PLC-γ1), and their activated (phosphorylated) forms (p-TrkB, p-Akt, p-Erk1/2, and p-PLC-γ1) in the cortex and striatum. D, E, Relative levels of TrkB receptors and downstream effectors in the cortex and striatum (n = 4–9 mice per genotype). One-way ANOVA analyses revealed that there was a significant effect of genotype on levels of striatal Akt (F(3,23) = 9.609, p < 0.001) and striatal p-Akt (F(3,23) = 3.928, p < 0.05), but not for other protein levels. Error bars represent SEs. Multiple comparisons using t test: *p < 0.05; **p < 0.01.