Skip to main content
. 2010 Nov 3;30(44):14708–14718. doi: 10.1523/JNEUROSCI.1637-10.2010

Figure 6.

Figure 6.

Effects of BDNF overexpression on gene expression of striatal neurons in YAC128 mice. A, Representative in situ hybridization images showing striatal levels of mRNAs for dopamine receptor D2 (Drd2), enkephalin (Penk), dopamine receptor D1a (Drd1a), and substance P (Tac1) in four genotypes of mice. B, Relative levels of Drd2, Penk, Drd1a, and Tac1 mRNAs in the striatum (n = 4 mice per genotype). Significant differences in abundance among the four genotypes were found for Drd2 mRNA (F(3,12) = 16.01, p < 0.001), Penk mRNA (F(3,12) = 13.16, p < 0.001), and Tac1 mRNA (F(3,12) = 4.328, p < 0.05) but not for Drd1a mRNA (F(3,12) = 1.479, p = 0.270). C, Representative Western blot of striatal DARPP-32. D, Relative levels of DARPP-32 in the striatum were not significantly different among four genotypes of mice (F(3,14) = 1.600, p = 0.234; n = 6 WT mice and 4 mice for each of the other 3 genotypes). Error bars represent SEs. Multiple comparisons using t test: *p < 0.05; **p < 0.01.