Figure 2.

T cell reconstitution is equivalent between Rg mice expressing GAD65-specific and control TCRs. A, Representative flow cytometric plot illustrating GFP⁺TCR⁺ cells (top panel) and CD4⁺TCR⁺ cells (bottom panel) in the spleens of representative TCR NOD.scid Rg mice. The GFP⁺TCR⁺ plots were gated on live cells and the CD4⁺TCR⁺ plots were gated on live, GFP⁺ cells. B, Mean fluorescence of TCR expression of GFP⁺ cells in spleens of Rg mice represented in A. C, Number of GFP⁺TCR⁺CD4⁺ cells in the spleens of TCR Rg mice represented in A. Data is representative of 6 experiments with 4–11 mice per TCR group.