Table 1.
Clinical and biochemical characteristics in A8+ PCOS, A8− PCOS and A8− Non-PCOS women.a
| A8+ PCOS Model-adjusted Mean (SD) [n] |
A8− PCOS Model-adjusted Mean (SD) [n] |
A8− Non-PCOS Model-adjusted Mean (SD) [n] |
A8+ PCOS vs. A8− PCOS P-valueb |
A8− PCOS vs. A8− Non-PCOS P-valueb |
|
|---|---|---|---|---|---|
| Biometrics | |||||
| Age (years) | 27.7 (1.6) | 27.1 (0.7) | 28.1 (9.0) | 1.00 | 1.00 |
| [40] | [40] | [40] | |||
| BMI (kg/m2) | 37.1 (8.2) | 33.2 (8.0) | 27.7 (6.1) | 0.14 | 0.01 |
| [40] | [40] | [40] | |||
| SBP (mm Hg) | 119.2 (14.4) | 117.6 (10.8) | 116.8 (8.2) | 1.00 | 1.00 |
| [39] | [34] | [37] | |||
| DBP (mmHg) | 75.7 (8.0) | 74.7 (7.6) | 71.8 (6.9) | 1.00 | 0.42 |
| [39] | [34] | [37] | |||
| TGF-β Superfamily | |||||
| TGF-β1 (ng/ml) | 26.9 (7.1) | 37.2 (12.5) | 28.8 (5.5) | 0.003 | 0.008 |
| [40] | [40] | [40] | |||
| TGF- β2 (pg/ml) | 188.3 (48.3) | 216.2 (117.6) | 314.8 (100.0) | 0.63 | 0.01 |
| [40] | [40] | [40] | |||
| Inhibin A (pg/ml)c | 3.6 (1.4, 8.1) | 1.5 (0.8, 2.4) | 11.9 (3.6, 23.8) | 0.11 | <0.001 |
| [40] | [40] | [40] | |||
| Inhibin B (pg/ml)c | 49.7 (20.1, 76.1) | 17.7 (7.9, 35.6) | 25.5 (7.2, 61.0) | 0.006 | 1.00 |
| [40] | [40] | [40] | |||
| AMH (ng/ml) | 7.9 (3.5) | 9.1 (5.2) | 3.0 (2.4) | 0.56 | <0.001 |
| [40] | [40] | [40] | |||
| Reproductive profile | |||||
| Total testosterone (ng/dl) | 79.6 (28.0) | 77.7 (19.0) | 31.0 (12.0) | 1.00 | < 0.001 |
| [40] | [40] | [40] | |||
| Unbound testosterone | 25.0 (9.0) | 23.4 (10.1) | 6.4 (3.4) | 0.93 | < 0.001 |
| (ng/dl) | [40] | [40] | [40] | ||
| SHBG (nmol/L) | 77.0 (19.0) | 84.9 (22.0) | 109.7 (69.2) | 0.81 | 0.20 |
| [36] | [34] | [37] | |||
| Ferriman-Gallwey | 11.0 (7.1) | 14.7 (7.1) | 6.6 (4.9) | 0.10 | <0.001 |
| hirsutism score | [37] | [39] | [33] | ||
| Metabolic profile | |||||
| Aldosterone (ng/dl) | 11.4 (6.8) | 7.6 (4.0) | 8.1 (5.5) | 0.04 | 1.00 |
| [40] | [40] | [40] | |||
| Glucose (mg/dl)d | 89.6 (11.1) | 86.2 (8.6) | 87.4 (7.8) | 0.33 | 1.00 |
| [40] | [40] | [40] | |||
| Insulin (µU/ml)e | 25.4 (13.3) | 21.4 (11.0) | 21.5 (9.2) | 0.34 | 1.00 |
| [40] | [40] | [40] | |||
| HOMA-IR | 3.2 (1.6) | 2.7 (1.3) | 2.7 (1.1) | 0.29 | 1.00 |
| [40] | [40] | [40] | |||
| LDL (mg/dl) | 117.4 (29.4) | 113.3 (31.3) | 115.2 (32.2) | 1.00 | 1.00 |
| [36] | [39] | [37] | |||
| Triglycerides (mg/dl) | 135.5 (82.2) | 156.0 (65.9) | 128.0 (25.8) | 0.63 | 0.16 |
| [37] | [40] | [37] |
a
Data are based on ANCOVA model adjusting for BMI, except for age and BMI which are based on ANOVA (unadjusted).
b
Bonferroni adjustment for multiple tests.
c
Data reported as median (25th percentile, 75th percentile) adjusted for BMI due to skewness.
d
To convert glucose to millimoles per liter, multiply by 0.05551.
e
To convert insulin to picomoles per liter, multiply by 6.945.