Table 1.
Baseline characteristics of the study population by treatment group
| Characteristic | Placebo | Salsalate | p value |
|---|---|---|---|
| n | 18 | 22 | – |
| Men/women (n) | 9/9 | 10/12 | 1.0 |
| Ethnicity (W/N/H) | 3/14/1 | 3/19/0 | 0.6 |
| Age (years) | 33 (8) | 29 (7) | 0.2 |
| BMI (kg/m2) | 38 (6) | 37 (5) | 0.7 |
| Body fat (%) | 38 (7) | 38 (6) | 0.9 |
| Fasting plasma glucose (mmol/l) | 5.06 (0.33) | 5.11 (0.33) | 0.9 |
| 2 h plasma glucose (mmol/l) | 6.61 (1.83) | 6.67 (1.17) | 0.9 |
| Fasting plasma insulin (pmol/l) | 63 (49, 90) | 80 (56, 104) | 0.3 |
| Basal EGP (μmol [kgEMBS]−1 min−1) | 11 (2) | 10 (2) | 0.2 |
| Clamp EGP (μmol [kgEMBS]−1 min−1) | 0 (0, 3) | 0 (0, 2) | 0.8 |
| Clamp Rd (μmol [kgEMBS]−1 min−1)a | 16 (13, 20) | 13 (11, 15) | 0.09 |
Unless otherwise stated, data are means (SD) or medians (25th, 75th percentile)
a
Rd normalised for steady-state plasma glucose and serum insulin concentrations
p values were determined by Mantel–Haenszel test on categories, Student’s t test on means and Wilcoxon’s U test on medians; W, Whites; N, Native Americans; H, Hispanics