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Effects of the NOS inhibitor, L-NNA (100 µM) on the relaxant responses to insulin (A, B) and (C, D) ACh (10 µM) in penile arteries from LZR and OZR. Data are shown as the means ± SEM of 6–8 arteries, 1–2 per animal. *P < 0.05, **P < 0.01, versus control arteries. Unpaired Student's t-test. ACh, acetylcholine; L-NNA, Nω-nitro-L-arginine; LZR, lean Zucker rat; NOS, nitric oxide synthase; OZR, obese Zucker rat; Phe, phenylephrine.
