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. Author manuscript; available in PMC: 2010 Nov 22.
Published in final edited form as: Curr Top Med Chem. 2009;9(13):1181–1193. doi: 10.2174/156802609789753644

Fig (3).

Fig (3)

The reporter inhibition-nonspecific activation paradox. A) The typical fate of a protein reporter being depleted over time via proteolysis and B) the stabilization and extension of reporter half-life through inhibitor binding and the false impression of activation.