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. Author manuscript; available in PMC: 2010 Nov 22.
Published in final edited form as: Curr Top Med Chem. 2009;9(13):1181–1193. doi: 10.2174/156802609789753644

Fig (8).

Fig (8)

Novel thioredoxin-glutathione reductase (TGR) Probes. A) The fluorescence TGR/Prx coupled enzyme assay developed using the reduction of fluorescence that occurs during NADPH consumption. B) The entire qHTS data set. Samples where the CRCs could be fit to the data are shown in blue (activating CRCs) or red (inhibitory CRCs), while data that did not show any CRC is shown in orange. C) The chemical structure of furoxan (7) D) The survival of ex-vivo S. mansoni adult worms at selected concentrations of furoxan. E) In vivo analysis of worm burdens following furoxan (IP administration) treatment in subpopulations of S. mansoni infected mice. Treatment 1 represents dosing during the larvae stage of parasite infection. Treatment 2 represents dosing during the juvenile stage of parasite infection. Treatment 3 represents dosing during the adult stage of parasite infection.