Table 1.

PDE isoform selectivity data for rolipram and NCGC116

	PDE isoform*	rolipram IC50/% inh.	6 IC50/% inh.
rolipram	PDE1A	inactive	inactive
	PDE1B	inactive	inactive
	PDE1C	inactive	26%
	PDE2A	inactive	41%
6 (NCGC00165289)	PDE3A	inactive	1.7 μM
	PDE3B	inactive	720 nM
	PDE4A1A	102 nM	12.9 nM
	PDE4B1	901 nM	48.2 nM
	PDE4B2	534 nM	37.2 nM
	PDE4C1	40%	452 nM
	PDE4D2	403 nM	49.2 nM
	PDE5A1	inactive	60%
	PDE7A	inactive	73%
	PDE7B	inactive	33%
	PDE8A1	inactive	57%
	PDE9A2	inactive	inactive
	PDE10A1	inactive	823 nM
	PDE11A4	inactive	inactive

^*data generated by BPS Biosciences (CA) [http://www.bpsbioscience.com] and represents either the IC50 value or the % inhibition at 10 uM of compound.