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. Author manuscript; available in PMC: 2010 Nov 22.
Published in final edited form as: Clin Cancer Res. 2009 Oct 6;15(20):6367–6377. doi: 10.1158/1078-0432.CCR-09-0910

Fig. 3.

Fig. 3

Effect of different schedules of administration on the efficacy of BSI-401 ip as single agent. Twenty athymic mice bearing orthotopic COLO357FG pancreatic tumors were randomly allocated (n= 5) to be treated with BSI-401 ip as indicated, or DMSO as control. A, B, Tumor volume following treatment, quantified as the sum of all detected photons within the region of the tumor per second. Means and SE are shown. C, Survival curves following treatment. Mice were sacrificed by carbon dioxide inhalation when evidence of advanced bulky disease was present. The day of sacrifice was considered the day of death for survival evaluation. D, In vivo levels of total poly(ADP)ribose polymers. Ten athymic mice bearing orthotopic COLO357FG pancreatic tumors were treated with a single injection of BSI 401 ip 200 mg/kg. Tumors from two mice were harvested at any timepoint as indicated. Each sample was analyzed in four replicates. Relative concentrations (dots) and means (lines) are shown. * P< 0.05 treatment versus control by one-way analysis of variance and Dunnett’s multiple comparison post test.