Table 3.
Mitochondrial protein changes related to paclitaxel quantified by iTRAQ were also measured by label-free quantitation methods
| IPI | ProteinName | Swiss-Prot | methods | OFF+T/OFF−T | ON−T/OFF−T | ON+T/OFF−T |
|---|---|---|---|---|---|---|
| IPI00002520 | Serine hydroxymethyltransferase, mitochondrial | P34897 | iTRAQ | 1.79 | 1.13 | 1.34 |
| IPI00219291 | ATP synthase f chain, mitochondrial | P56134 | iTRAQ | 1.73 | 1.15 | 1.73 |
| LC-MS | 1.70 | 1.16 | 1.99 | |||
| IPI00029557 | GrpE protein homolog 1, mitochondrial | Q9HAV7 | iTRAQ | 1.65 | 1.30 | 1.46 |
| IPI00009960 | Mitochondrial inner membrane protein | Q16891 | iTRAQ | 1.64 | 1.20 | 1.05 |
| IPI00215916 | cytochrome c | P00001 | iTRAQ | 1.61 | 1.21 | 1.73 |
| LC-MS | 1.19 | 1.00 | 1.27 | |||
| IPI00031522 | Trifunctional enzyme alpha subunit, mitochondrial | P40939 | iTRAQ | 1.55 | 0.80 | 1.19 |
| SC | 3.01 | 3.00 | 6.06 | |||
| IPI00014230 | Complement component 1, mitochondrial | Q07021 | iTRAQ | 1.47 | 1.17 | 1.25 |
| SC | 1.59 | 0.60 | 0.40 | |||
| IPI00024919 | Thioredoxin-dependent peroxide reductase, mitochondrial | P30048 | iTRAQ | 1.40 | 1.05 | 1.39 |
| SC | 1.25 | 0.50 | 1.00 | |||
| IPI00024993 | Enoyl-CoA hydratase, mitochondrial | P30084 | iTRAQ | 1.38 | 0.81 | 1.12 |
| SC | 1.67 | 1.33 | 1.33 | |||
| IPI00329351 | 60 kDa heat shock protein, mitochondrial | P10809 | iTRAQ | 1.33 | 1.05 | 1.31 |
| IPI00007765 | Stress-70 protein, mitochondrial | P38646 | iTRAQ | 1.33 | 1.05 | 1.12 |
| LC-MS | 1.71 | 1.21 | 1.47 | |||
| SC | 1.75 | 1.50 | 1.65 | |||
| IPI00021785 | Cytochrome c oxidase polypeptide Vb, mitochondrial | P10606 | iTRAQ | 1.31 | 1.38 | 2.03 |
| IPI00304802 | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | P36957 | iTRAQ | 1.31 | 0.92 | 1.23 |
| IPI00022793 | Trifunctional enzyme beta subunit, mitochondrial | P55084 | iTRAQ | 1.30 | 1.29 | 1.35 |