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. Author manuscript; available in PMC: 2010 Nov 22.
Published in final edited form as: J Fam Ther. 2009 May 1;31(2):126–154. doi: 10.1111/j.1467-6427.2009.00459.x

TABLE 2.

Summary of process-outcome studies derived from controlled trials of family-based treatments for adolescent substance use

Process study Treatment
models
Sample N: sex,
ethnic status
Parent study Main findings
Schmidt et al., 1996 MDFT 29: 72 per cent
male, 55 per cent
EA
Liddle et al., 2001 Observed improvements in parenting
practices predicted decreased drug use and
behaviour problems
Huey et al., 2000a MST 54: 80 per cent
male, 54 per cent
EA, 46 per cent AA
Henggeler et al., 2002 Treatment adherence predicted improved
family relations and decreased delinquent
peer affiliation, which in turn were related to
reduced delinquency
Shelef et al., 2005 MDFT 65: 85 per cent
male, 47 per cent
EA, 47 per cent AA
Dennis et al., 2004 Observed parent therapeutic alliance
predicted premature termination; observed
adolescent alliance predicted drug use, and
this relation was moderated by parent alliance
Tetzlaff et al., 2005 MET/CBT-5
MET/CBT-12
FSN
ACRA
MDFT
430: 83 per cent
male, 61 per cent
EA, 30 per cent AA
Dennis et al., 2004 Adolescent therapeutic alliance predicted
decreased drug use at 3 and 6 months post-
intake but did not predict longer drug use
trajectories; treatment satisfaction did not
predict use
Diamond et al., 2006 MET/CBT-5
MET/CBT-12
FSN
ACRA
MDFT
400: 81 per cent
male, 61 per cent
EA, 32 per cent AA
Dennis et al., 2004 Adolescent-rated, but not therapist-related,
early session therapeutic alliance predicted
reduced drug use and related problems;
neither set of alliance ratings was associated
with treatment attendance
Hogue et al., 2006b MDFT
CBT-I
100: 81 per cent
male, 68 per cent
AA, 20 per cent EA,
12 per cent HA
Liddle et al., 2008 In MDFT, observed early session parent
therapeutic alliance predicted reduced drug
use and behaviour problems; observed early
adolescent alliance was related to change in
behaviour problems; in CBT, adolescent
alliance did not predict outcome
Hogue et al., 2006a MDFT 63: 83 per cent male,
71 per cent AA, 19
per cent EA, 10 per
cent HA
Liddle et al., 2008 Observed family-focused treatment techniques
predicted improved internalized distress and
family cohesion, and also improved behaviour
problems and family conflict when adolescent
focus was high; observed adolescent-focused
techniques predicted improved cohesion and
conflict
Robbins et al., 2006 MDFT
(therapeutic
alliance)
30 (adolescents and
their families): 80
per cent male, 80
per cent AA, 17 per
cent EA, 3 per cent
HA
MDFT
RCT
There is no relationship between therapeutic
alliance and treatment response; both
adolescent–therapist and mother–therapist
alliances discriminated between dropout and
completed families
Hogue et al., 2008 MDFT
CBT-I
136: 81 per cent
male, 70 per cent
AA, 20 per cent EA,
10 per cent HA
Liddle et al., 2008 In CBT, observed treatment adherence
predicted decreased drug use; in CBT and
MDFT, adherence predicted reduced
behaviour problems (linear effect) and
internalized distress (curvilinear effect);
observed therapist competence did not predict
outcome in either group

Note: Studies are listed in order of publication year, from earliest to most recent. Treatment process variables derived from non-participant observational measures are prefaced with ‘observed’.

MDFT = Multidimensional Family Therapy; MST = Multisystemic Therapy; MET/CBT-5/12 = Motivational Enhancement Therapy plus Cognitive-behavioural Therapy–Group (5 or 12 sessions); FSN = Family Support Network; ACRA = Adolescent Community Reinforcement Approach; CBT-I = Cognitive-behavioral Therapy–Individual

HA = Hispanic American; EA = European American; AA = African American.

a

In a related study with the same sample, Schoenwald et al. (2000) examined the relation between subdimensions of treatment adherence and the mediating variables (family functioning, parental monitoring, peer relations) described in the Huey et al. (2000) study.