Table 3.
Mitochondria targeting signals/motifs and delivered therapeutic agents.
| Targeting motif | Therapeutic | Ref. |
|---|---|---|
| (2-oxo-ethyl)-triphenyl-phosphonium | Nitroxide (4-amino-2,2,6,6-tetramethyl-piperidine-1-oxyl) | [374] |
| Rhodamine β | Porphyrin | [375] |
| Stearyltriphenyl phosphonium | Liposome-based nanocarrier containing ceramide | [376] |
| Triphenylphosphonium | Ubiquinol antioxidant | [183] |
| Dequalinium | DNA | [190] |
| MLSCTSPLLRGACHNMGAAKALRLRWTVPPAVLIALG SGALYTTSGQTLYYKNSVQQTD | Phospholipase A ortholog (AoPlaA) | [377] |
| MLSRAVCGTSRQLAPALGYLGSRQ | Protein transduction domain of HIV-1 TAT protein | [378] |
| MSATRMQLLSPRNVRLLSRGRSELFAGGSGGGPRVRSLISP PLSSSSPGRALSSVSATRRGLPKEKMTENGVSSRAKVLT IDT | Alanine aminotransferase | [379] |
| MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQ | Tumor suppressor p53 | [212] |
| MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQ | Dihydrofolate reductase | [213] |