Structured Interview Used to Assess for Depression as Specified by the NIMH Provisional Diagnostic Criteria for Depression in Alzheimer Disease

The presence of each symptom should be assessed over the preceding 2 weeks
1. “I am going to ask you some questions about (your/the participant’s) mood. Has there been a period of time when (you were/the participant was) feeling depressed or down most of the day? What was that like? Was this a change from the usual?” IF YES: “How long did it last? As long as 2 weeks?”
Clinically significant depressed mood:	Yes	No	Not Determined
2. “What about losing interest in things (you/the participant) usually enjoy(s)? IF YES: “Was this a change from the previous level of functioning? How long did it last? As long as 2 weeks?”
Decreased positive affect or pleasure	Yes	No	Not Determined
3. “Did (you/the participant) tend to withdraw from social contacts and (your/their) customary activities?”
Social isolation or withdrawal	Yes	No	Not Determined
4. “(Have you/Has the participant) lost or gained any weight?” IF YES: “How much? (Were you/Was the participant) trying to lose weight?” IF NO: “How was (your/the participant’s) appetite? What about compared to (your/the participant’s) usual appetite? Did you have to force (yourself/the participant) to eat? Eat (more/less) than usual?”
Disruption in appetite	Yes	No	Not Determined
5. How (have you/has the participant) been sleeping? Trouble falling asleep, waking frequently, trouble staying asleep, waking too early, or sleeping too much? How many hours a night compared to the usual?
Disruption in sleep	Yes	No	Not Determined
6. (Have you/Has the participant) been so fidgety or restless that (you were/the participant was) unable to sit still?” IF YES: “Was it so bad that other people noticed it? What did they notice? Was it a change from (your/the participan t’s) typical behavior?” IF NO: “What about the opposite- talking or moving more slowly than is normal for (you/the participant)? Was it so bad that other people noticed it? What did they notice? Was it a change from (your/the participant’s) typical behavior?”
Psychomotor changes	Yes	No	Not Determined
7. “Have (you/the participant) been feeling more irritable than usual?”
Irritability	Yes	No	Not Determined
8. What has (your/the participant’s) energy been like? Tired all the time?” IF YES: “A change from (your/the participant’s) typical behavior?”
Fatigue or loss of energy	Yes	No	Not Determined
9. “How (do you/does the participant) feel about (yourself/himself/herself)? Worthless?” IF YES: “Is this a change from (your/the participant’s) typical behavior?”
Feelings of worthlessness	Yes	No	Not Determined
10. “Were things so bad that (you were/the participant was) thinking a lot about death or that (you/the participant) would be better off dead? What about thinking of hurting (yourself/himself/herself)?
Recurrent thoughts of death	Yes	No	Not Determined