Table 1.

Demographics and MRI volumes for FTLD-FUS and FTLD-TDP

	FTLD-FUS (n=3)	FTLD-TDP (n=10)	FTLD-TAU (n=10)	p values
Sex (M:F)	2:1	4:6	6:4	0.58
Years of Education	15 (12-18)	13 (8-18)	15 (8-20)	0.43
Age at onset (years)	54.8 (49.5-65.0)	64.0 (45.0-77.0)	61.2 (40.6-76.0)	0.30
Age at death (years)	59.1 (52.9-69.8)	72.1 (56.3-83.1)	68.6 (47.0-83.0)	0.13
Age at MRI scan	57.0 (51.5-67.0)	67.7 (53.3-79.5)	64.7 (41.9-79.3)	0.20
Time from onset to scan (years)	2.2 (1.5-3.0)	3.7 (1.0-8.3)	3.5 (1.3-6.1)	0.47
Time from scan to death (years)	2.1 (1.4-2.8)	4.4 (1.9-7.6)	3.9 (0.6-6.7)	0.12
MMSE at scan/30	27 (26-28)	23 (11-29)	26 (22-30)	0.51
CDR-SB at scan	5.0 (1.5-8.5)	6.0 (0.5-18.0)	2.6 (0-6.5)	0.26
Caudate volume*	0.23 (0.20-0.25)	0.35 (0.27-0.48)	0.37 (0.29-0.47)	0.02
Frontal grey matter volume*	7.2 (6.7-7.8)	7.0 (5.1-9.4)	8.1 (6.7-9.7)	0.12
Total grey matter volume*	37.5 (36.2-38.6)	34.4 (30.3-42.0)	40.0 (35.4-46.5)	0.02
Caudate/total grey matter volume	0.62 (0.52-0.69)	1.02 (0.86-1.25)	0.92 (0.76-1.02)	0.01
Frontal grey matter /total grey matter volume	19.3 (17.9-20.1)	20.3 (16.7-23.1)	20.2 (18.4-23.0)	0.46
Caudate/frontal grey matter volume	3.3 (2.6-3.7)	5.0 (4.1-5.9)	4.6 (3.8-5.5)	0.01

^*Volumes are shown as a percentage of TIV, calculated using the following formula: (volume/TIV)100

Data shown as mean and range. CDR-SB = Clinical Dementia Rating sum of boxes; MMSE = Mini-Mental State Examination