Table II.
Characteristics of leukemias initiated by the cooperation of PML-RARα and MYC
Characteristics | PR+Myc+/− | PR+Myc+/+ | PR+MYCΔMBII | PR+MYC | PR+MYCT58A |
Myeloid Leukemia (%) | 31 | 67 | 100 | 89 | 100 |
Median Latency (d) | 339 | 258 | 92 | 76 | 70 |
SKY analysis | |||||
No. cases | 8 | 15 | 10 | 8 | 4 |
Clonal abnormality (%) | 8 (100) | 14 (93) | 8 (80) | 1 (13) | 1 (25) |
Karyotype Complexity | Complex | Intermediate | Simple | Simple | Simple |
Recurring clonal abnormalities (%) | |||||
−2 or del(2) | 1 (13) | 1 (7) | 0 (0) | 0 (0) | 0 (0) |
+4 or dup(4) | 1 (13) | 2 (13) | 0 (0) | 0 (0) | 0 (0) |
+6 | 2 (25) | 2 (13) | 0 (0) | 0 (0) | 0 (0) |
+7 | 2 (25) | 1 (7) | 0 (0) | 0 (0) | 0 (0) |
+8 | 8 (100) | 7 (47) | 0 (0) | 0 (0) | 0 (0) |
+10 | 6 (75) | 5 (33) | 5 (50) | 0 (0) | 0 (0) |
+12 | 2 (25) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
+14 | 1 (13) | 4 (27) | 0 (0) | 0 (0) | 0 (0) |
+15 | 5 (63) | 9 (60) | 0 (0) | 1 (13) | 0 (0) |
+16 | 1 (13) | 5 (33) | 0 (0) | 0 (0) | 0 (0) |
+17 | 2 (25) | 2 (13) | 0 (0) | 0 (0) | 0 (0) |
+18 or partial trisomy | 1 (13) | 2 (13) | 0 (0) | 0 (0) | 0 (0) |
−X/−Y | 4 (50) | 8 (53) | 4 (40) | 1 (13) | 1 (25) |