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. 2010 Nov 22;207(12):2537–2541. doi: 10.1084/jem.20102260

Figure 1.

Figure 1.

Model of the multiprotein complexes orchestrating gene expression or repression in erythroid cells. Comparison of GATA-1, SCL/TAL1, and LDB1 whole-genome occupancy maps with gene expression profiling data suggests that the GATA-1/SCL/TAL1–LMO2–LDB1–E2A pentameric complex, as well as a GATA-1–independent SCL/TAL-1–containing complex, largely activate gene expression. GATA-1 may also activate gene expression in coordination with KLF1 (activating complexes, green box). GATA-1 might repress gene expression via a multi-step process. Interaction with the transcriptional repressor GFI-1B recruits the LSD1/coREST complex, which results in removal of the activating H3K4me2 mark. To permanently silence gene expression, GATA-1 can recruit the PRC2 complex (EED, Ezh2, and Suz12) resulting in H3K27 trimethylation and gene repression. The SCL/TAL1 complex can recruit the corepressors ETO2 and Mtgr1 resulting in SCL/TAL1 mediated gene silencing (repressing complexes, red box).