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. 2010 Nov 22;207(12):2689–2701. doi: 10.1084/jem.20101111

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© 2010 Baumann et al.

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Figure 4. — CD14 is important for the proinflammatory response to CpG-DNA in vivo. WT or CD14^−/− mice were i.p. injected with 8 nmol CpG-DNA. After 4 h, mice were sacrificed. (A) The levels of the proinflammatory cytokines IL-6, KC (IL-8), IL-1β, and MCP-1 in peritoneal lavage were analyzed by ELISA. (B) Peritoneal lavage was taken, and total cells, neutrophils, and macrophages were counted. Differences in cytokine values of WT and CD14^−/− stimulation pairs were tested for significance using the one-way analysis of variance and Tukey’s post test. Significant alterations in pattern are marked with an asterisk (*, P < 0.05 vs. WT mice; Mann–Whitney T test). In A, P = 0.0434, P = 0.0005, and P = 0.0029 for IL-6, IL-8, and IL-1β, respectively. In B, P = 0.0002 for neutrophils. Data are presented as mean ± SD and are representative of two independent experiments, each performed with eight mice/group.