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Overall severity and time course of facial irritation for 5-FU cream 0.5% during 1, 2, and 4 weeks of treatment. Severity ratings are based on the following scale: 0 = none, 1 = mild, 2 = moderate, 3 = severe. (Reprinted with permission from Cutis. 2002;70:335–339. ©2002 Quadrant HealthCom.30)
