Table III.
Correlation between transcriptional alterations seen in JEG-3 cells over expressing STOX1A and alterations observed in decidua basalis tissue from pre-eclamptic and/or FGR pregnancies.
| Correlation coefficient2 (Spearman r) | P-value | |
|---|---|---|
| Pre-eclampsia | 0.16 | 0.004* |
| Pre-eclampsia with FGR1 | 0.23 | 0.00008* |
| FGR | 0.09 | 0.17 |
1≤2 SD of expected weight, confirmed by at least one of the following: reduced fundal height in serial measurements, serial ultrasound biometry identifying failure to grow along a consistent centile or abnormal umbilical artery wave form.
2correlation between the degrees of up/down-regulation of 259 pre-eclampsia related genes from the study of Rigourd et al. (comparing JEG-3 cells over expressing STOX1 with mock-transfected JEG-3 cells) with the present study (comparing decidua basalis samples from patients with pre-eclampsia and/or FGR with control decidua basalis samples).
*P < 0.01.