FIG. 1.

The influence of the application of the investigated enrollment criteria (time window ≤ 8 h; age at injury ≤ 65 years; ≥1 reactive pupil; motor score > 1; GCS ≤ 8) on recruitment and outcome distribution in three surveys and six randomized controlled trials (RCTs) of the International Mission on Prognosis and Analysis of Clinical Trials in TBI (IMPACT) database. For each study, the selected (gray bars) and the excluded patients (black bars) are depicted. The width of the bars indicates the numbers of selected and excluded patients.