Table 1.
Distribution of Patient Characteristics Across Three Surveys and Six RCTs from the IMPACT Study
| |
|
|
Pupillary reactivity |
Motor score |
|
|---|---|---|---|---|---|
| Time window (hours), median (interquartile range) | Age (years), median (interquartile range) |
(1) both pupils pos (2) one pupil pos (3) both pupils neg |
(1,2) none/extension (3) abnormal flexion (4) normal flexion (5,6) localizes/obeys (9) untestable/missing |
GCS, median (interquartile range) | |
| 243 (40%) | |||||
| 300 (50%) | 74 (12%) | ||||
| TCDB (n = 604) | 1.2 (0.8–3.1) | 26 (21–40) | 55 (9%) | 122 (20%) | 6 (4–8) |
| 249 (41%) | 134 (22%) | ||||
| 31 (5%) | |||||
| 198 (25%) | |||||
| 429 (54%) | 37 (5%) | ||||
| UK4 (n = 791) | 3.5 (2.0–8.9) | 36 (22–55) | 115 (15%) | 141 (18%) | 6 (4–8) |
| 247 (31%) | 221 (28%) | ||||
| 194 (25%) | |||||
| 230 (28%) | |||||
| 527 (64%) | 55 (7%) | ||||
| EBIC (n = 822) | 3.7 (1.5–8.0) | 38 (24–59) | 87 (11%) | 113 (14%) | 7 (4–11) |
| 208 (25%) | 281 (34%) | ||||
| 143 (17%) | |||||
| 671 (30%) | |||||
| 1256 (57%) | 166 (8%) | ||||
| Total surveys (n = 2217) | 2.8 (1.2–6.1) | 32 (22–53) | 257 (12%) | 376 (17%) | 7 (4–9) |
| 704 (32%) | 636 (29%) | ||||
| 368 (16%) | |||||
| 280 (34%) | |||||
| 583 (71%) | 92 (11%) | ||||
| HIT II (n = 819) | 2.0 (1.0–4.0) | 33 (22–49) | 101 (12%) | 181 (22%) | 8 (6–10) |
| 135 (16%) | 207 (25%) | ||||
| 59 (7%) | |||||
| 152 (15%) | |||||
| 709 (68%) | 132 (13%) | ||||
| TIUS (n = 1041) | .7 (0.5–1.2) | 30 (23–41) | 122 (12%) | 300 (29%) | 7 (6–10) |
| 210 (20%) | 457 (44%) | ||||
| 0 (0%) | |||||
| 141 (13%) | |||||
| 813 (73%) | 237 (21%) | ||||
| TINT (n = 1118) | 1.2 (0.8–2.1) | 30 (21–45) | 170 (15%) | 327 (29%) | 6 (5–7) |
| 135 (12%) | 413 (37%) | ||||
| 0 (0%) | |||||
| 655 (43%) | |||||
| 779 (52%) | 165 (11%) | ||||
| PEGSOD (n = 1510) | 1.1 (0.6–2.2) | 27 (20–38) | 160 (11%) | 334 (22%) | 5 (3–7) |
| 571 (38%) | 356 (24%) | ||||
| 0 (0%) | |||||
| 55 (13%) | |||||
| 316 (78%) | 91 (22%) | ||||
| SLIN (n = 409) | No data | 28 (21–43) | 79 (19%) | 127 (31%) | 6 (5–7) |
| 14 (3%) | 136 (33%) | ||||
| 0 (0%) | |||||
| 264 (29%) | |||||
| 612 (67%) | 143 (16%) | ||||
| SAPHIR (n = 919) | 2.3 (1.0–4.2) | 32 (20–38) | 307 (33%) | 223 (24%) | 6 (5–8) |
| 0 (0%) | 286 (31%) | ||||
| 3 (0%) | |||||
| 1547 (27%) | |||||
| 3812 (66%) | 860 (15%) | ||||
| Total RCTs (n = 5816) | 1.2 (0.7–2.6) | 30 (21–43) | 939 (16%) | 1492 (26%) | 7 (5–10) |
| 1065 (18%) | 1855 (32%) | ||||
| 62 (1%) |