Table 4.
Evidence of association in CLHNS mothers of SNPs previously reported to be associated with adiponectin
| SNP (alias) | Closest gene | Chr | Position | Allele 1 > 2 | MAF | Imputation qualitya | Baseline model |
bLD r2 | Conditioned Pc | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P-value | ||||||||||
| rs16861194 (−11426 A>G) | ADIPOQ | 3 | 188,042,119 | A>G | G: 0.18 | 0.95 | −0.021 (0.019) | 0.26 | 0.013 | 0.95 | (21) |
| rs17300539 (−11391 G>A) | ADIPOQ | 3 | 188,042,154 | G>A | A: 0.00 | – | – | – | ND | ND | (16) |
| rs266729 (−11377 C>G) | ADIPOQ | 3 | 188,042,168 | G>C | G: 0.27 | 0.96 | −0.038 (0.016) | 0.018 | 0.029 | 1.7E−04 | (16) |
| rs182052 | ADIPOQ | 3 | 188,043,476 | A>G | A: 0.45 | 1.00 | −0.017 (0.014) | 0.22 | 0.057 | 9.1E−04 | (19) |
| rs17366568 | ADIPOQ | 3 | 188,053,147 | G>A | A: 0.03 | 0.98 | 0.034 (0.043) | 0.44 | 0.001 | 0.54 | (29) |
| rs2241766 (+45 T>G) | ADIPOQ | 3 | 188,053,594 | G>T | G: 0.26 | 0.79 | 0.047 (0.017) | 0.0077 | ND | 0.10 | (13) |
| rs1501299 (+276 G>T) | ADIPOQ | 3 | 188,053,825 | G>T | T:0.39 | 0.90 | −0.028 (0.015) | 0.059 | 0.000 | 0.75 | (13) |
| rs3774261 | ADIPOQ | 3 | 188,054,253 | G>A | G:0.37 | 1.00 | −0.056 (0.014) | 7.0E−05 | 0.019 | 0.066 | (23) |
| rs6773957 | ADIPOQ | 3 | 188,056,407 | G>A | G:0.37 | 1.00 | −0.056 (0.014) | 7.0E−05 | 0.019 | 0.066 | (23) |
| rs1063537 | ADIPOQ | 3 | 188,056,769 | C>T | T:0.22 | 0.96 | −0.041 (0.017) | 0.017 | 0.020 | 0.12 | (11) |
| rs4311394 | ARL15 | 5 | 53,336,419 | A>G | G:0.44 | 0.99 | 0.009 (0.014) | 0.53 | ND | ND | (24) |
| rs1774950 | LYZL1 | 10 | 82,085,093 | T>C | T:0.44 | 0.99 | 0.005 (0.014) | 0.73 | ND | ND | (23) |
| rs7195409 | CDH13 | 16 | 82,085,093 | A>G | G:0.10 | 0.99 | 0.032 (0.023) | 0.16 | 0 | 0.10 | (23) |
Analyses were adjusted for age, age2, household assets, natural log-transformed household income and menopausal status (n = 1776). β (SE) indicates the effect size and standard error of each additional copy of Allele 1 on natural log-transformed adiponectin level. The SNP rs17300539 (−11391G>A) was monomorphic in direct TaqMan genotyping.
aMACH r2 was applied to indicate the imputation quality of the imputed SNPs.
bLinkage disequilibrium (LD) measure r2 with the index SNP of each locus (ADIPOQ: rs864265 and CDH13: rs3865188), based on the HapMap CHB + JPT combined sample.
cP-values for SNP association when conditional analysis was performed using the index SNP of each locus; ND, no data. Position for all SNPs is relative to NCBI Build 36 assembly.