Table 5.
Association of adiponectin-associated SNPs with other metabolic traits
| SNP | Log_BMI | Waist circumference | Log_TG | Log_HDL-C | Log_LDL-C | Log_glucose | Log_insulin | Log_HOMA-IR | Log_HOMA-β | |
|---|---|---|---|---|---|---|---|---|---|---|
| CLHNS mothers (n = 1776) | ||||||||||
| rs3865188 CDH13 | β (SE) | −0.007 (0.006) | −0.72 (0.35) | −0.009 (0.016) | −0.000 (0.009) | 0.004 (0.010) | −0.005 (0.007) | −0.022 (0.021) | −0.027 (0.024) | −0.008 (0.021) |
| P-value | 0.25 | 0.042 | 0.58 | 0.97 | 0.66 | 0.49 | 0.29 | 0.25 | 0.72 | |
| rs864265 ADIPOQ | β (SE) | 0.004 (0.009) | 0.30 (0.54) | 0.049 (0.025) | 0.002 (0.013) | 0.016 (0.015) | 0.005 (0.011) | 0.041 (0.031) | 0.046 (0.036) | 0.026 (0.032) |
| P-value | 0.64 | 0.58 | 0.047 | 0.89 | 0.26 | 0.68 | 0.19 | 0.20 | 0.42 | |
| rs11924390 KNG1 | β (SE) | 0.006 (0.006) | 0.30 (0.36) | 0.005 (0.017) | 0.000 (0.009) | 0.011 (0.010) | −0.004 (0.007) | 0.032 (0.021) | 0.028 (0.024) | 0.040 (0.022) |
| P-value | 0.34 | 0.41 | 0.77 | 0.99 | 0.25 | 0.56 | 0.13 | 0.25 | 0.063 | |
| CLHNS offspring (n = 1774) | ||||||||||
| rs3865188 CDH13 | β (SE) | −0.001 (0.005) | 0.08 (0.26) | −0.017 (0.017) | −0.007 (0.008) | −0.000 (0.010) | −0.005 (0.003) | −0.021 (0.019) | −0.026 (0.020) | −0.008 (0.019) |
| P-value | 0.77 | 0.75 | 0.32 | 0.38 | 0.99 | 0.091 | 0.27 | 0.18 | 0.67 | |
| rs864265 ADIPOQ | β (SE) | −0.019 (0.007) | −1.07 (0.39) | −0.008 (0.025) | 0.021 (0.013) | −0.007 (0.015) | 0.002 (0.005) | −0.091 (0.028) | −0.089 (0.030) | −0.097 (0.028) |
| P-value | 0.0086 | 0.0066 | 0.76 | 0.091 | 0.63 | 0.61 | 0.0011 | 0.0027 | 6.3E−04 | |
| rs11924390 KNG1 | β (SE) | −0.003 (0.005) | −0.06 (0.26) | −0.009 (0.017) | 0.000 (0.008) | 0.002 (0.010) | 0.003 (0.003) | 0.007 (0.019) | 0.010 (0.020) | −0.004 (0.019) |
| P-value | 0.51 | 0.82 | 0.58 | 0.99 | 0.88 | 0.34 | 0.73 | 0.63 | 0.85 | |
CLHNS mothers analysis was adjusted for age, age2, household assets, natural log-transformed household income and menopausal status; CLHNS offspring analysis was adjusted for sex, household assets and natural log-transformed household income. The reference alleles are the same as those indicated in Table 2.