Table 3. Associations of genetic variation in driver kinase loci and risk of breast cancer by ERα tumor status†.
BMPR1A, rs12765929 | ||||||||||
Controls | ERα-negative | ERα-positive | ||||||||
n | % | n | % | OR | 95% CI | n | % | OR | 95% CI | |
G/G | 514 | 59.1 | 189 | 64.5 | 1.00 | 389 | 58.4 | 1.00 | ||
G/T | 306 | 35.2 | 96 | 32.8 | 0.87 | 0.65–1.16 | 243 | 36.5 | 1.07 | 0.86–1.33 |
T/T | 50 | 5.7 | 8 | 2.7 | 0.45 | 0.21–0.98 | 34 | 5.1 | 0.93 | 0.59–1.48 |
Total | 870 | 293 | 666 | |||||||
Trend | 0.79 | 0.62–1.00 | 1.02 | 0.86–1.21 | ||||||
Ptrend = 0.050 | Ptrend = 0.81Pinteraction = 0.024 |
Adjusted by age.