Table 1.

Comparison of reporter expression in Sox10-Venus and various other mice with NC lineage-labeling

Tissues	Sox10-Venus	Sox10-Cre	P0-Cre	Wnt1-Cre	Ht-Pa-Cre
Dorsal root ganglia	+	+	+	+	+
Sympathetic ganglia	+	+	+	+	+
Melanoblasts	+	+	+	+	+
Enteric nervous system	+	+	+	+	+
Superior/jugular ganglion	+	+	+	+	+
Aortae	+	+	+	+	+
Craniofacial mesenchyme	+	+	+	+	+
Otic vessicle	+	+	+	+	+
Oligodendroglia	+	+	-	-	-
Ventral neural tube	+	+	-	-	-
Developing limb	+	+	-	-	-

Reporter gene expression patterns at the embryonic stage are compared in various mice developed to trace neural crest derivatives: Sox10-Venus, Sox10(S4F)-Cre [26], P0-Cre [5,15], Wnt1-Cre [14,16,26,31,32], and Ht-Pa-Cre [16,26]. All these lines have similar labeling patterns in both NC-lineage tissues (DRG, sympathetic ganglia, melanoblasts, enteric nervous system, superior/jugular ganglion, aorta, craniofacial mesenchyme) and in tissues not in the NC lineage (otic vesicle, oligodendroglial cells, and OPCs). In the developing limbs of Sox10-Venus and Sox10-Cre mice, which reflect the endogenous Sox10 expression profile, the reporter fluorescence clearly labeled oligodendroglial cells and the peripheral nervous network. Immunohistochemistry did not detect any ectopic reporter gene expression in any tissues from the embryonic Sox10-Venus mice.