Table 1.

Summary of characteristics of five clinically tested anti-EpCAM monoclonal antibodies analyzed side by side.

Antibody	Binding Affinity [nM]			Binding Domain	ADCC	CDC	Inhibition of MCF-7 Breast Cancer Cell Proliferation	Tolerability in Clinical Trials
	KD	Kon [M/s]	Koff[1/s]		Mean EC50 in [ng/ml]	Mean at 20 μg/ml[%]
Edrecolomab	1530	2.81 × 104	0.043	Exon 2	264	33	Not Significant	High
Chimeric Edrecolomab	2095	1.67 × 104	0.035	Exon 2	671	60	Not Significant	High
3622W94	0.19	9.49 × 104	1.8 × 10-5	Exon 2	38	70	Not Significant	Low (Pancreatitis)
ING-1	0.16	1.96 × 104	3.2 × 10-5	Exon 2	14	63	Not Significant	Low (Pancreatitis)
Adecatumumab	91	3.46 × 105	0.0316	Exon 5	175	29	Yes	High