Table 2.

Genotypes for the proposed Idd11 haplotype

^aSequence variant 1, ss262803379 (129,638,063); 2, rs32465505 (129,638,192); 3, rs27507073 (129,638,344); 4, rs27507071 (129,638,482); 5, rs27507066 (129,639,302); 6, rs27507065 (129,639,451); 7, ss262803405 (129,640,008); and 8, rs48826903 (129,640,045). Chr 4 positions are listed in parentheses and based on NCBI build 37 assembly, mm9. Boldface text indicates sequence identical to C57BL/6 sequence.

^bIdd11B mice exhibit a similar diabetes incidence curve to NOD and Idd11E mice (Brodnicki et al. 2000, 2005).

^cIdd11E represents a crossover with a complex conversion tract as confirmed by direct sequencing of a PCR product encompassing markers 1–4 derived from genomic DNA from five independent Idd11E mice.

^dVariants shared by NON, CTS, BALB/c, NZO, NZW, C3H, CBA, DBA/2, A/J, ALR, ALS, AKR, 129/Sv, WSB.

^eVariants shared by SJL, SWR, FVB.

^fVariants shared by C57BL/6, C57BL/10, NOR, NZB, DBA/1, MOLF.

^gSpontaneous diabetes has not been reported for PWD and CAST mouse strains. Note that sequencing of genomic DNA obtained from independent NOD and B6 strains from the Jackson Laboratory were identical to the NOD and B6 strains within our mouse colony. Sequence variation across this region showing the individual mouse strains is provided in Supplemental Table 4.