Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Dec;20(12):1639–1650. doi: 10.1101/gr.112128.110

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 by Cold Spring Harbor Laboratory Press

PMC Copyright notice

Figure 6. — Tissue-specific cleavage events. (A) Cluster analysis of the expression of the 500 genes containing the highest exonic CAGE tag frequency shows the up-regulation (red) and down-regulation (green) of mRNA cleavage in human THP-1 cell differentiation. Expression level was determined as the normalized CAGE tag frequency mapping to coding exons. (B) Genome Browser view of human SMG5 gene with CAGE tag mapping (blue panels) across different THP1 time points shows specific cleavage event (red arrow) at 96 h post-PMA-stimulation. (C) Mouse Mtap1b gene showing CAGE tags mapping in the visual (green panel), somatosensory (blue panel) cortex, and hippocampus (beige panel). (D) Mouse Tbr1 gene shows alternative exonic CAGE tag locations preferred between the visual and somatosensory cortex (red arrow) and the hippocampus (blue arrow). (E) CAGE tags mapping (blue panel) to Bptf (violet bars) bisect distinct encoded protein domains (purple bars), potentially generating alternative protein-coding isoforms. (Tpm) Tags per million.