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. 2010 Jun 28;2010:814176. doi: 10.4061/2010/814176

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Copyright © 2010 Jeffrey S. Larson et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Configuration of the H2T and H2D assay. (a) Configuration of the HER2 total assay consists of two antibodies specific to unique epitopes on the c-terminus of the HER2 protein. One antibody (Ab-1) is conjugated to a VeraTag molecule (V) and the other is conjugated to biotin (Ab-2). The photosensitizer molecule (PM) brings the strepavidin-methylene blue in close proximity to the antibodies. (b) Configuration of the H2D assay consists of one antibody that is specific for a unique epitope on the HER2 protein. The same antibody is conjugated either to a VeraTag (V; Ab-1) or to biotin (Ab-1). The photosensitizer molecule (PM) brings the strepavidin-methylene blue in close proximity to the antibodies.