Table 1.
Mean basal levels of monoamines and their metabolites in the four different limbic brain regions (± SEM) of 34-35 day old Wistar and WKY rats (pmol/mg protein).
| Brain Region | Strain | DOPA | DA | DOPAC | HVA | 5HT | 5HIAA |
|---|---|---|---|---|---|---|---|
| Nac | Wistar | 7.03 ± 3.22 | 70.7 ± 7 | 55.6 ± 8.2 | 30.9 ± 1.4 | 2.95 ± 0.2 | 11.1 ± 1.28 |
| WKY | 3.31 ± 0.95 | 69.6 ± 4 | 53.6 ± 2.6 | 26 ± 1.5# | 1.9 ± 0.71 | 5.67 ± 1.05* | |
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| VTA | Wistar | 2 ± 1.7 | 10.9 ± 5.1 | 16.57 ± 9.17 | 1.49 ± 0.68 | 3.48 ± 2.32 | 4.58 ± 2.96 |
| WKY | 14.15 ± 1.7** | 10.6 ± 6.7 | 3.12 ± 1.3 | 5.55 ± 4.8 | 2.48 ± 1.2 | 1.16 ± 0.83 | |
|
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| Hypothalamus | Wistar | 49.7 ± 6.14 | 197 ± 52.1 | 57.6 ± 2.9 | 30.4 ± 8.2 | 16.56 ± 4.4 | 114 ± 10.2 |
| WKY | 88.2 ± 17.2# | 96 ± 30.4 | 107.7 ± 7.7** | 31.8 ± 9.5 | 17.08 ± 4.6 | 83.8 ± 5.7* | |
|
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| Amydgala | Wistar | 11.84 ± 1.67 | 6.88 ± 1.2 | 2.59 ± 1 | 4.70 ± 1.1 | 2.25 ± 0.2 | 1.38 ± 0.8 |
| WKY | 8.35 ± 1.2 | 7.91 ± 1.5 | 4.74 ± 1.2 | 2.86 ± 1.6 | 2.02 ± 1.1 | 4.29 ± 0.9* | |
**P < .01 Wistar versus WKY; *P < .05 Wistar versus WKY; # P < .1 Wistar versus WKY.